Have questions?

There's a lot more to know about Holigos® and you probably have some questions of your own. Take a look at our FAQ page for answers and information on everything from how to take Holigos® to our money-back guarantee.

General Questions

We all have a unique microbiome and experience different digestive symptoms. That’s why we created two different types of Holigos® products. Both target the source of your gut issues and can help you achieve your digestive health goals. Use this chart to understand the difference and determine which is best for you.


Holigos® IBS | Restore



Holigos® IBS Restore is intended for you if you’ve been medically diagnosed with IBS or suffer with the same severe symptoms such as stomach pain, bloating, constipation and/or diarrhea. If you’re looking to optimize your digestive health or you experience only occasional digestive issues, Holigos® Maintain is recommended for you.

Clinically proven to lessen days with stomach pain, reduce bloating severity, and increase your number of normal stools so constipation and diarrhea are reduced. User-proven for proactively maintaining digestive health and
managing occasional digestive upsets.

0.19 oz (5.5 g) daily dose (1 stick pack per day) 0.12 oz (3.3 g) daily dose (1 stick pack per day)

Contains proprietary formulation of both:
  • 2’-Fucosyllactose
  • Lacto-N-neotetraose
  • 2’-Fucosyllactose

Nonprescription medical food to be used under medical supervision Dietary supplement

Available in 28 daily stick packs Available in 28 daily stick packs


Human milk oligosaccharides (HMOs) are a type of complex carbohydrate found in breast milk. They’re known as natural digestive nutrients because of their prebiotic properties. Prebiotics work with your body’s own good bacteria, unlike probiotics which add foreign bacteria to your body. 

So simply put, HMOs work by selectively nourishing and stimulating the growth of your own good gut bacteria, activating them to thrive and outperform bad bacteria. 

Their benefits in breast milk have long been known to help build and fortify healthy guts in infants, and studies show they can benefit adult gut health as well by targeting the source of gut issues and making real changes to your digestive system.

We mirrored these natural digestive nutrients to create our own unique and targeted nutrient formulation. Holigos® doesn’t contain human milk, but just like nature’s own HMOs, our ingredients are natural to your body and can help restore balance in your gut microbiome, ultimately helping relieve your digestive symptoms.

Yes. Holigos® IBS Restore has been clinically proven to nutritionally manage all types of IBS-C (constipation), D (diarrhea), and M (constipation and diarrhea), as well as severe IBS-related symptoms. We’re also the only product that normalizes bowel movements for every type of IBS.

Life-impacting results we’ve seen: 

  • Fewer days with abdominal pain (over a 10-day period, users had 3 more pain-free days)
  • More normal bowel movements; constipation and diarrhea reduced
  • Bloating severity reduced by almost 60%
  • Users reported 48% improvement on quality-of-life measures such as energy, mood, and irritability

Learn more about our clinical results and what they can mean for you.

Probiotics used for the digestive system work by introducing foreign bacteria into your body rather than rebalancing your own microbiome. That “outside” bacteria may or may not survive in your body, depending upon your gut’s environment, so it can be less effective. Yogurt is a good example of a probiotic food. Holigos® is what’s known as a targeted prebiotic containing human milk oligosaccharides (HMOs). Unlike probiotics, HMOs are unique in that they nourish only your good gut bacteria so that they produce the nutrients your body needs to help restore balance in your gut. In other words, HMOs help restore and fortify your gut from within.

Our focus is health and safety, so we presented our scientific-based conclusion that the ingredients found in Holigos® are safe to both the US Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA).

Both agencies, independently, have reviewed the ingredients in Holigos® and have accepted them as safe.

Additionally, in clinical studies, hundreds of babies and adults have consumed our human milk oligosaccharides, even at higher doses than the daily dose found in Holigos®. No issues with safety and no severe side effects have been reported.

Holigos® has been formulated for adults and children 12 years of age and older. Note: In the event a healthcare provider recommends Holigos® to a child under the age of 12, the dosage should be as directed by the healthcare provider.

We produce the ingredients in Holigos® at our own large-scale, food-grade manufacturing site in Esbjerg, Denmark. 

Holigos® IBS Restore and Holigos® Maintain are then packaged under current Good Manufacturing Practices (cGMP) quality standards in an FDA-audited packaging facility in the USA.

Get to know Glycom, the maker of Holigos®, and learn more about how Holigos® was born.

Product Specific Questions

No. The HMOs (human milk oligosaccharides) found in Holigos® are not from human milk.

We mirrored the nutritive process and gut-fortifying power of nature’s HMOs to create our own unique and targeted nutrient formulation.

Like nature’s HMOs, our ingredients are natural to your body and can help restore balance in your gut microbiome, and ultimately help relieve your digestive symptoms.

See how Holigos® works to build and fortify your gut health.

Let’s start with what human milk oligosaccharides (HMOs) are: a type of complex carbohydrate found in breast milk. They’re known as natural digestive nutrients because of their prebiotic properties. Simply put, HMOs work by selectively nourishing and stimulating the growth of your own good gut bacteria, activating them to thrive and outperform bad bacteria.

There are over 200 types of HMOs, and we’ve mirrored two widely studied types of these natural digestive nutrients to create our own unique and targeted nutrient formulation. Holigos® doesn’t contain human milk, but just like nature’s own HMOs, our ingredients are natural to your body and can help restore balance in your gut microbiome, and ultimately help relieve your digestive symptoms.

Holigos® IBS Restore is a proprietary blend of two HMOs (human milk oligosaccharides):

  • 2’-Fucosyllactose
  • Lacto-N-neotetraose

Holigos® Maintain contains:

  • 2’-Fucosyllactose

Yes! We know that people often like to try before they buy, so we’ve supplied many health care providers with full 28-stick sample boxes to give to their patients. If you would like a sample, please ask your healthcare provider.

Getting Started

Holigos® is designed to fit into your life. You can take it at any time of day. The convenient on-the-go stick packs make it easy to work into your daily routine at any time.

However, it is important that you take Holigos® regularly, so we suggest taking it at the same time each day so it becomes part of your ritual. Take a look at how Alex, a long-time Holigos® user, incorporates it into his breakfast routine.

Holigos® is a soluble powder that you can easily mix with any food or beverage, warm or cold — so do what works best for you, like adding it to your breakfast or favorite drink.

Holigos® is odor free and has little to no taste (slightly sweet if mixed in water).

Take a look at our Instagram page to find recipes and fun “mixtures” to incorporate Holigos® into your daily routine!

We recommend taking one stick pack per day, or as directed by your doctor.

Some people temporarily take half a stick per day if they're experiencing anything more than the usual initial side effects such as increased gas or stomach rumbling. These symptoms are perfectly normal and are actually an indication that Holigos® is beginning to improve your microbiome.

We know life happens, so if you miss a day, it is not necessary to take a double dose afterwards.

Since we make real changes in your gut microbiome, it is not unusual to experience some mild side effects when you start taking Holigos®.

Research shows that over 96% of people who participated in our clinical study found Holigos® to be tolerable. The most common temporary side effects were mild gastrointestinal (GI) symptoms such as abdominal pain, gas, and bloating. These are perfectly normal and actually an indication that your microbiome is beginning to improve.

These sensations tend to disappear without any intervention after a few days, though for some people it may take slightly longer for their system to settle. While it might feel a little unpleasant during these first days, know that these are signs that your microbiome is changing to help you reclaim control of your digestive health, so it’s worth sticking with it.

If you are still experiencing these symptoms after the first few weeks but they are manageable, it is perfectly safe to continue with the products. Your gut will find a new balance by itself within the first month or two.

If, however, you experience any more serious side effects, such as nausea or increased IBS symptoms, you should stop taking the product and seek advice from your doctor.

Most of our users report feeling results within 1–2 weeks. If you have any questions along the way, The Holigos® team is here to help. Feel free to email us at contact@holigos.com or reach out to us on Facebook or Instagram at any time.

Dietary Restrictions

Holigos® may contain traces of lactose (milk), however the amount of lactose contained in Holigos® is very small and ordinarily too low to trigger any symptoms of lactose intolerance.

Many lactose intolerant people have used and are using Holigos® safely, so yes, you can take Holigos® if you are lactose intolerant.

We're sensitive to food sensitivities and allergies, which is why we created Holigos® to be free from: 

  • Artificial flavors, sweeteners, and coloring
  • Yeast
  • Preservatives
  • Gluten
  • GMOs
  • Soy, peanuts, tree nuts, wheat, eggs, fish, and shellfish

We do not believe that Holigos® meets the strict definition of vegan.

Each stick pack of Holigos® IBS Restore contains 12 calories.

Each stick pack of Holigos® Maintain contains 10 calories.

It is safe to take Holigos® with other supplements like vitamins, enzymes, or probiotics (although you do not need probiotics if you take Holigos®). Holigos® has not been tested in drug interaction trials. If you are taking other medications, speak with your physician before starting Holigos®.

Yes, Holigos® is FODMAP-friendly! Not all oligosaccharides are covered by the "O" in FODMAP. The FODMAP oligosaccharides generally contain the sugar, fructose, and are found in vegetables, fruits, legumes, etc. These FODMAP oligosaccharides are digested by a large number of intestinal bacteria, many of which produce gases that generate symptoms such as bloating.

The human milk oligosaccharides in Holigos® do not contain fructose. Also, because of their unique structure, only a very small number of specific intestinal bacteria can digest them, and these specific bacteria are not known gas producers. This is confirmed by our clinical studies where Holigos® IBS Restore reduced bloating and gas.


Renewals are scheduled to be delivered every 28 days starting from your first delivery.

Each box comes with 28 stick packs to be taken once a day. Once you’re near the end of the month, keep your eye on the mail for a new box.

Holigos® Microbiome Health is part of your daily routine for better digestive health. Subscribing ensures that you always have your Holigos® on hand and you never miss a dose.

Our goal is to make daily digestive wellness as easy as a single click so you can set it and forget it — but rest easy knowing you can cancel anytime. Simply log into your account to skip a shipment or cancel your subscription.

You can skip one or more shipments or cancel your subscription at any time.

Yes, you may buy subscriptions for others. You will need to place an individual order for each subscription to allow for different shipping addresses.

The new website will recognize your email address which is tied to your subscription  information. If you have forgotten your password, enter the email address associated with your account and you will be sent a link to reset your password.

Shipping & Returns

You will receive a shipping confirmation email within 24–48 hours after you have purchased. This email will have all the information about when your Holigos® will arrive.

Standard delivery is free of charge.

Expedited and Priority shipping are available at a small surcharge that is calculated during checkout.

We do not ship outside the US.

We believe that Holigos® will work for you, but if for any reason you would like to return the product, we offer a full money-back guarantee. Simply reach out to us at cs@i-healthinc.com within 30 days of receiving your Holigos®.

We always appreciate the opportunity to make things right, and we will refund you if we haven't lived up to expectations.

We will send an email notification including tracking information when your Holigos® box has shipped.

Of course you can! Just log in to your account to change your address for future orders.