FUT2 gene alterations

Our genes store information and contain instructions that play an essential role in proper functioning of our bodies. One such gene is the FUT2 gene. This gene enables us to produce the enzyme, α1,2-fucosyltransferase and functions in producing glycans. These glycans are fiber-like molecules found in saliva and in the mucus of our intestine. Why are these glycans so important you may ask — they play an important role in gut functioning and in the body’s immune response.

Health issues that disrupt our daily lives can occur when our genes are altered. About 20% of the population have an altered FUT2 gene. What this means is that people with this gene alteration (called FUT2 non-secretors) are unable to produce the enzyme, α1,2-fucosyltransferase. This leads to an inability to produce certain glycans, specifically the glycan ending found in 2’-fucosyllactose (2’FL), which in turn leads to health consequences that are discussed below.


What are these health consequences?

People with FUT2 gene alterations have less bifidobacteria in their intestines, also known as our beneficial or good bacteria, resulting in a weaker intestinal barrier and an unbalanced immune system. In addition to these health symptoms, this population may have a higher risk of developing type 1 diabetes, celiac disease, and inflammatory bowel disease. They may also be prone to a higher risk of developing kidney disease, urinary tract infections, and candida infections. Furthermore, these diseases and infections have been linked to a gut microbiome with less good bacteria. If you are looking for ways to change your cycle of gut symptoms into a cycle of gut health, continue reading below.

One of the main suspects in creating this vicious cycle is our intestinal microbiome (the bacteria resident in our intestines). Many IBS patients have an unbalanced intestinal microbiome which can lead to a dysfunctional intestinal barrier (leaky gut). This can cause an overactive immune system and dysfunctional interaction with the nervous system. Therefore, this possible cause and effect relationship between the unbalanced intestinal microbiome and dysfunctional intestinal barrier may be a fundamental cause of IBS.


How can you improve your health symptoms?

It only makes sense for people with FUT2 gene alterations to seek out dietary sources that have the 2’FL ingredient. The good news is, both Holigos® IBS Restore and Holigos® Maintain contain the key ingredient, 2’FL.

Holigos® IBS Restore selectively nourishes your good bacteria, activating them to thrive and help strengthen your intestinal wall and balance your immune system. Holigos® IBS Restore has been clinically proven to:

  • Reduce bloating
  • Increase the number of normal bowel movements
  • Decrease number of days with stomach pain
  • Improve quality of life measures including energy, mood, and anxiety (based on user information)


In a trial of over 1400 people, the majority of people who used using Holigos® IBS Restore were either satisfied or very satisfied with their experience and found it easy to take. A user who has the FUT2 gene alteration and also suffers from IBS-D and celiac disease told us that after taking Holigos® IBS Restore for three weeks, she felt a significant improvement in her symptoms.

For those with FUT2 gene alterations who have only occasional gastrointestinal issues, but a low number of the good bacteria, Holigos® Maintain is recommended. Holigos® Maintain can help you maintain a balanced gut microbiome.


Holigos® Maintain

Holigos® Maintain is a dietary supplement for proactive digestive health and support with occasional digestive issues.†

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