Holigos® IBS | Restore

Relief for patients that’s safe, well-tolerated, and effective in a once-daily dose.1-6

Help your patients discover the difference with a free 28-day supply of Holigos® IBS Restore.

Already Received Samples?

Holigos® IBS | Restore

Relief for patients that’s safe, well-tolerated, and effective in a once-daily dose.1-6

Help your patients discover the difference with a free 28-day supply of Holigos® IBS Restore.

Already Received Samples?

Clinical Benefits

Holigos® IBS Restore is clinically proven to help provide relief in all IBS subtypes.1-2

In a 12-week, open-label, multi-center study (N=317),* Holigos® IBS Restore demonstrated multiple benefits1-2

Decreased Severity

IBS symptom severity changed from severe to mild by Week 12, as measured by the IBS-severity scoring system (IBS-SSS)

Over 86% of patients had a clinically significant improvement in their IBS-SSS total score by Week 12

  • A reduction of 50 points or more in the IBS-SSS total score is considered clinically significant7

58% decrease in abdominal pain severity per IBS-SSS pain component, P<0.0001

Overall IBS Severity Score

Fewer Days with Pain

Reduced from an average of 6.0 to 2.5 days within the prior 10 days, P<0.00012‡

More Normal Stools

Over 4.6-fold increase in normal stools from a baseline of 9% as measured by the Bristol Stool Form Scale (BSFS)2||

Improved Quality of Life

48% increase in quality-of-life (QOL) scores using the IBS-QOL assessment, P<0.0001

Patients experienced improvement in abdominal pain, bloating, and stool consistency in as early as 4 weeks.1-2

Similar efficacy shown across all IBS subtypes.1-2

All results are based on the intention-to-treat population.

Clinical white paper

Download our clinical white paper to learn about the benefits of Holigos® IBS Restore.

Clinical white paper

Download our clinical white paper to learn about the benefits of Holigos® IBS Restore.

Holigos® IBS Restore helps reduce symptoms by providing dietary management for patients with IBS.

Mechanism of Action of Holigos® IBS Restore

While others target the symptoms, we target the source.

1

Bacterial dysbiosis is a key driver of IBS pathology and is common in patients with IBS.10-15

2

Microbiome dysbiosis can impair normal gut metabolism, which can exacerbate symptoms of IBS.10,11,13,16,17

3

Abnormal gut metabolism disrupts gut barrier function and can exacerbate symptoms of IBS.13,18-20

4

The glycans in Holigos® IBS Restore act as selective prebiotics to help rebalance the gut microbiome and increase production of beneficial metabolites.2-4,9,21,22

5

The glycans in Holigos® IBS Restore improve gut barrier integrity and gut motility.2,10,11,18

Holigos® IBS Restore helps reduce symptoms by providing dietary management for patients with IBS.1,2

Safety & Tolerability

Holigos® IBS Restore is safe and well-tolerated.1,3-6

In a double-blinded, placebo-controlled trial, it was demonstrated that2,3:

No difference in reported adverse events between Holigos® IBS Restore and placebo.
No serious adverse events with
Holigos® IBS Restore or placebo reported.
Common side effects associated with Holigos® IBS Restore included mild local reactions in the gut, such as abdominal pain, distension, and flatulence.

The ingredients in the Holigos® family of products are safe and well-tolerated by infants, children, adults, and patients with IBS.3-6

Dosing

Holigos® IBS Restore is a medical food available as a once-daily dose.

Holigos® IBS Restore is easy to take and has been formulated to help normalize the gut microbiota.2-5

Holigos® IBS Restore is a proprietary formulation of the glycans 2’-FL and LNnT. The ingredients in Holigos® IBS Restore have been positively reviewed by the FDA and EFSA and accepted as safe.23-26

Holigos® IBS Restore does not contain gluten, artificial colors or flavors, added sugar, or yeast. Shelf-stable, Holigos® IBS Restore does not have refrigeration or special storage requirements.

2'-FL=2'-Fucosyllactose; LNnT=Lacto-N-neotetraose.

Dosing

Holigos® IBS Restore is a medical food available as a once-daily dose.

Holigos® IBS Restore is easy to take and has been formulated to help normalize the gut microbiota.2-5

Holigos® IBS Restore is a proprietary formulation of the glycans 2’-FL and LNnT. The ingredients in Holigos® IBS Restore have been positively reviewed by the FDA and EFSA and accepted as safe.23-26

Holigos® IBS Restore does not contain gluten, artificial colors or flavors, added sugar, or yeast. Shelf-stable, Holigos® IBS Restore does not have refrigeration or special storage requirements.

2'-FL=2'-Fucosyllactose; LNnT=Lacto-N-neotetraose.

The proof is in our product.

Let your patients sample Holigos® IBS Restore free to discover the difference.

If you are a registered healthcare professional with patients who have IBS, we would be delighted to provide you with free samples and coupons for your patients.

Please complete the form below to receive your free shipment of Holigos® IBS Restore. Please allow 1–3 weeks for delivery. Samples may come in multiple packages, depending on the quantity requested.

*Required Field

Interested in wholesale opportunities?

Connect with our team today:

Email: contact@holigos.com

Footnotes & References

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