Holigos® IBS | Restore

Relief for patients that’s safe, well-tolerated, and effective in a once-daily dose.1-6

Help your patients discover the difference with a free 28-day supply of Holigos® IBS Restore.

Already Received Samples?

Holigos® IBS | Restore

Relief for patients that’s safe, well-tolerated, and effective in a once-daily dose.1-6

Help your patients discover the difference with a free 28-day supply of Holigos® IBS Restore.

Already Received Samples?

Clinical Benefits

Holigos® IBS Restore is clinically proven to help provide relief in all IBS subtypes.1-2

In a 12-week, open-label, multi-center study (N=317),* Holigos® IBS Restore demonstrated multiple benefits1-2

Decreased Severity

IBS symptom severity changed from severe to mild by Week 12, as measured by the IBS-severity scoring system (IBS-SSS)

Over 86% of patients had a clinically significant improvement in their IBS-SSS total score by Week 12

  • A reduction of 50 points or more in the IBS-SSS total score is considered clinically significant7

58% decrease in abdominal pain severity per IBS-SSS pain component, P<0.0001

Overall IBS Severity Score

Fewer Days with Pain

Reduced from an average of 6.0 to 2.5 days within the prior 10 days, P<0.00012‡

More Normal Stools

Over 4.6-fold increase in normal stools from a baseline of 9% as measured by the Bristol Stool Form Scale (BSFS)2||

Improved Quality of Life

48% increase in quality-of-life (QOL) scores using the IBS-QOL assessment, P<0.0001

Patients experienced improvement in abdominal pain, bloating, and stool consistency in as early as 4 weeks.1-2

Similar efficacy shown across all IBS subtypes.1-2

All results are based on the intention-to-treat population.

Clinical white paper

Download our clinical white paper to learn about the benefits of Holigos® IBS Restore.

Clinical white paper

Download our clinical white paper to learn about the benefits of Holigos® IBS Restore.

Holigos® IBS Restore helps reduce symptoms by providing dietary management for patients with IBS.

Mechanism of Action of Holigos® IBS Restore

While others target the symptoms, we target the source.

1

Bacterial dysbiosis is a key driver of IBS pathology and is common in patients with IBS.10-15

2

Microbiome dysbiosis can impair normal gut metabolism, which can exacerbate symptoms of IBS.10,11,13,16,17

3

Abnormal gut metabolism disrupts gut barrier function and can exacerbate symptoms of IBS.13,18-20

4

The glycans in Holigos® IBS Restore act as selective prebiotics to help rebalance the gut microbiome and increase production of beneficial metabolites.2-4,9,21,22

5

The glycans in Holigos® IBS Restore improve gut barrier integrity and gut motility.2,10,11,18

Holigos® IBS Restore helps reduce symptoms by providing dietary management for patients with IBS.1,2

Safety & Tolerability

Holigos® IBS Restore is safe and well-tolerated.1,3-6

In a double-blinded, placebo-controlled trial, it was demonstrated that2,3:

No difference in reported adverse events between Holigos® IBS Restore and placebo.
No serious adverse events with
Holigos® IBS Restore or placebo reported.
Common side effects associated with Holigos® IBS Restore included mild local reactions in the gut, such as abdominal pain, distension, and flatulence.

The ingredients in the Holigos® family of products are safe and well-tolerated by infants, children, adults, and patients with IBS.3-6

Dosing

Holigos® IBS Restore is a medical food available as a once-daily dose.

Holigos® IBS Restore is easy to take and has been formulated to help normalize the gut microbiota.2-5

Holigos® IBS Restore is a proprietary formulation of the glycans 2’-FL and LNnT. The ingredients in Holigos® IBS Restore have been positively reviewed by the FDA and EFSA and accepted as safe.23-26

Holigos® IBS Restore does not contain gluten, artificial colors or flavors, added sugar, or yeast. Shelf-stable, Holigos® IBS Restore does not have refrigeration or special storage requirements.

2'-FL=2'-Fucosyllactose; LNnT=Lacto-N-neotetraose.

Dosing

Holigos® IBS Restore is a medical food available as a once-daily dose.

Holigos® IBS Restore is easy to take and has been formulated to help normalize the gut microbiota.2-5

Holigos® IBS Restore is a proprietary formulation of the glycans 2’-FL and LNnT. The ingredients in Holigos® IBS Restore have been positively reviewed by the FDA and EFSA and accepted as safe.23-26

Holigos® IBS Restore does not contain gluten, artificial colors or flavors, added sugar, or yeast. Shelf-stable, Holigos® IBS Restore does not have refrigeration or special storage requirements.

2'-FL=2'-Fucosyllactose; LNnT=Lacto-N-neotetraose.

The proof is in our product.

Let your patients sample Holigos® IBS Restore free to discover the difference.

If you are a registered healthcare professional with patients who have IBS, we would be delighted to provide you with free samples and coupons for your patients.

Thank you for your interest in Holigos® IBS Restore. Unfortunately our sample program is unavailable at this time.  If you provide your contact details below, we will notify you with updates to the program and availability.

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Email: contact@holigos.com

Footnotes & References

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