HOLIGOS® IN ACTION
While others target the symptoms, we target the source.
Bacterial dysbiosis can be common in patients with IBS.

Microbiome dysbiosis can impair normal gut metabolism.

Detrimental metabolites accumulate
Contributing to IBS

The bile acid profiles becomes inbalanced
Leading to disruption

Short-chain fatty acids (SCFAs) are depleted
Resulting in impaired gut barrier
Abnormal gut metabolism disrupts gut barrier function and can exacerbate symptoms of IBS.

Epithelial cell damage

Leaky gut
The glycans in Holigos® IBS Restore act as selective prebiotics to help rebalance the gut microbiome and increase production of beneficial metabolites. Holigos® IBS Restore is a medical food for the dietary management of IBS.

Holigos® reaches the gut intact
Providing nutrients

Rebalance the gut microbiome
Microbiota populations increased

Increase production of SCFAs
Epithelial cells are supplied to improve gut health
The glycans in Holigos® IBS Restore improve gut barrier integrity and gut motility.

Balance restored

Healthy epithelial cells
Safety & Tolerability
A double-blinded, placebo-controlled trial demonstrated†:
No difference in reported adverse events between Holigos® IBS Restore and placebo.
No serious adverse events with Holigos® IBS Restore or placebo reported.
Common side effects associated with Holigos® IBS Restore included mild local reactions in the gut, such as abdominal pain, distension, and flatulence.
Frequently Asked Questions
Holigos® is a soluble powder that you can easily mix with any food or beverage, warm or cold — so do what works best for you, like adding it to your breakfast or favorite drink.
Holigos® is odor free and has little to no taste (slightly sweet if mixed in water).
Take a look at our Instagram page to find recipes and fun “mixtures” to incorporate Holigos® into your daily routine!
Since we make real changes in your gut microbiome, it is not unusual to experience some mild side effects when you start taking Holigos®.
Research shows that over 96% of people who participated in our clinical study found Holigos® to be tolerable. The most common temporary side effects were mild gastrointestinal (GI) symptoms such as abdominal pain, gas, and bloating. These are perfectly normal and actually an indication that your microbiome is beginning to improve.
These sensations tend to disappear without any intervention after a few days, though for some people it may take slightly longer for their system to settle. While it might feel a little unpleasant during these first days, know that these are signs that your microbiome is changing to help you reclaim control of your digestive health, so it’s worth sticking with it.
If you are still experiencing these symptoms after the first few weeks but they are manageable, it is perfectly safe to continue with the products. Your gut will find a new balance by itself within the first month or two.
If, however, you experience any more serious side effects, such as nausea or increased IBS symptoms, you should stop taking the product and seek advice from your doctor.
Holigos® has been formulated for adults and children 12 years of age and older. Note: In the event a healthcare provider recommends Holigos® to a child under the age of 12, the dosage should be as directed by the healthcare provider.

Safe and Well-Tolerated
Holigos® IBS Restore is a medical food available as a once-daily dose.
Holigos® IBS Restore ingredients were reviewed and a no questions asked letter was issued by the FDA.
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