Holigos® IBS Restore helps patients suffering from all IBS subtypes to have more consistent stools, less abdominal pain, and decreased bloating.1,2
Clinical Benefits
Holigos® IBS Restore is clinically proven to help provide relief in all IBS subtypes.1-2
In a 12-week, open-label, multi-center study (N=317),* Holigos® IBS Restore demonstrated multiple benefits1-2
Decreased Severity
IBS symptom severity changed from severe to mild by Week 12, as measured by the IBS-severity scoring system (IBS-SSS)‡
Over 86% of patients had a clinically significant improvement in their IBS-SSS total score by Week 12‡
- A reduction of 50 points or more in the IBS-SSS total score is considered clinically significant7
58% decrease in abdominal pain severity per IBS-SSS pain component, P<0.0001‡
Overall IBS Severity Score

Fewer Days with Pain

Reduced from an average of 6.0 to 2.5 days within the prior 10 days, P<0.00012‡
More Normal Stools

Over 4.6-fold increase in normal stools from a baseline of 9% as measured by the Bristol Stool Form Scale (BSFS)2||
Improved Quality of Life

48% increase in quality-of-life (QOL) scores using the IBS-QOL assessment, P<0.00012¶
Patients experienced improvement in abdominal pain, bloating, and stool consistency in as early as 4 weeks.1-2
Similar efficacy shown across all IBS subtypes.1-2
All results are based on the intention-to-treat population.
Holigos® IBS Restore helps reduce symptoms by providing dietary management for patients with IBS.
Mechanism of Action of Holigos® IBS Restore
While others target the symptoms, we target the source.
Bacterial dysbiosis is a key driver of IBS pathology and is common in patients with IBS.10-15


Microbiome dysbiosis can impair normal gut metabolism, which can exacerbate symptoms of IBS.10,11,13,16,17



Abnormal gut metabolism disrupts gut barrier function and can exacerbate symptoms of IBS.13,18-20


The glycans in Holigos® IBS Restore act as selective prebiotics to help rebalance the gut microbiome and increase production of beneficial metabolites.2-4,9,21,22



The glycans in Holigos® IBS Restore improve gut barrier integrity and gut motility.2,10,11,18


Holigos® IBS Restore helps reduce symptoms by providing dietary management for patients with IBS.1,2
Safety & Tolerability
Holigos® IBS Restore is safe and well-tolerated.1,3-6
In a double-blinded, placebo-controlled trial, it was demonstrated that2,3:


Holigos® IBS Restore or placebo reported.

The ingredients in the Holigos® family of products are safe and well-tolerated by infants, children, adults, and patients with IBS.3-6