Diet is a core element in the pathogenesis of IBS

The pathogenesis of IBS is exceedingly complex and multi-factorial, but diet plays a key role. The gut microbiota is recognized as a key factor in the pathogenesis of IBS1 and diet is a major determinant of the gut microbiota2. Also, about two thirds of patients develop symptoms soon after eating a meal, especially foods rich in fats3 and certain carbohydrates4, particularly FODMAPs5. Therefore, diet is both a trigger of symptoms and a core element of IBS pathogenesis.

Medical nutrition is specifically tailored for the patient's distinct nutritional needs and addresses dietary causes

Medical nutrition involves managing a patient using specifically-tailored, nutritional interventions under the guidance of a medical professional. It is much more than taking supplements or probiotics. This can be done using guidelines for first-line, dietary management of IBS, for example, the NICE guidelines6. An alternative is to use medical foods. Medical nutrition works; a recent survey7 of 1500 US gastroenterologists found that 90% of respondents believed dietary management was at least as good or better than existing pharmacologic therapies for IBS.

Holigos™ IBS is a medical food specifically formulated to address the specific nutritional needs of IBS patients and restore gut homeostasis

Medical foods are a specific class of food product defined in the Orphan Drug Act of 1988 [21 USC 360ee (b)(3)]. They are specifically formulated for the dietary management of a defined disease or condition for which there are distinctive nutritional requirements. Holigos® IBS is formulated to modulate the gut microbiota of all sub-types of IBS patients, which increases the activity of beneficial bacteria. Holigos® IBS also increases nutrients and metabolites such as Short Chain Fatty Acids (SCFAs).

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Simrén M. Manipulating the Gut Microbiome as a Treatment Strategy for Functional Gastrointestinal Disorders. Gastroenterology; 2018; Oct, 155(4):960-962.  2 Conlon MA and Bird AR. The Impact of Diet and Lifestyle on Gut Microbiota and Human Health.  Nutrients. 2015; Jan; 7(1): 17–44.  3 Simrén M, Abrahamsson H, Björnsson ES. An exaggerated sensory component of the gastrocolonic response in patients with irritable bowel syndrome. Gut; 2001; 48: 20–7.  4 Shepherd SJ, Parker FC, Muir JG, Gibson PR. Dietary triggers of abdominal symptoms in patients with irritable bowel syndrome: randomized placebo-controlled evidence. Clin Gastroenterol Hepatol; 2008; 6:765–71.  5 Staudacher HM, et al. Mechanisms and efficacy of dietary FODMAP restriction in IBS. Nat Rev Gastroenterol Hepatol; 2014; 11:256-266.  6 National Institute for Health and Care Excellence. Irritable bowel syndrome in adults: diagnosis and management. Clinical Guideline [CG61]. Published: February 2008. Last updated: April 2017. Available at: https://www.nice.org.uk/guidance/cg617 Lenhart A, Ferch C, Shaw M, and Chey WD. Use of Dietary Management in Irritable Bowel Syndrome: Results of a Survey of over 1500 United States Gastroenterologists. J Neurogastroenterol Motil.; 2018; Jul 30;24(3):437-451.